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Description
Claudin 1 Recombinant Rabbit mAb (SDT-025-43)Product Specification Host Rabbit Antigen CLDN1 Synonyms Claudin 1,CLD1, SEMP1 Immunogen Synthetic Peptide Accession O95832 Clone Number SDT 025 43 Antibody Type Rabbit mAb Isotype IgG2b Application IHC P Reactivity Hu, Ms, Rt Predicted Reactivity Bv Purification Protein A Research Area Signal Transduction Concentration 0. 5mg ml Molecular Weight 22. 7kDa Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05%BSA,
Product Specification
| Host | Rabbit |
| Antigen | CLDN1 |
| Synonyms | Claudin-1,CLD1, SEMP1 |
| Immunogen | Synthetic Peptide |
| Accession | O95832 |
| Clone Number | SDT-025-43 |
| Antibody Type | Rabbit mAb |
| Isotype | IgG2b |
| Application | IHC-P |
| Reactivity | Hu, Ms, Rt |
| Predicted Reactivity | Bv |
| Purification | Protein A |
| Research Area | Signal Transduction |
| Concentration | 0.5mg/ml |
| Molecular Weight | 22.7kDa |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:250 |
Background
Claudin-1 is a protein that in humans is encoded by the CLDN1 gene.It belongs to the group of claudins.
Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are composed of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.
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