ICAM-1/CD54 Fc Chimera Protein, Human
SKU: 46250705950

ICAM-1/CD54 Fc Chimera Protein, Human

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Description

ICAM-1/CD54 Fc Chimera Protein, HumanProduct Specification Species Human Synonyms BB2, CD54 antigen, CD54, cell surface glycoprotein P3. 58, human rhinovirus receptor, ICAM1, ICAM 1, intercellular adhesion molecule 1 (CD54) Amino Acid Sequence Gln28 Glu480, with C terminal Human IgG1 Fc

Product Specification


Species Human
Synonyms BB2, CD54 antigen, CD54, cell surface glycoprotein P3.58, human rhinovirus receptor, ICAM1, ICAM-1, intercellular adhesion molecule 1 (CD54)
Amino Acid Sequence

Gln28-Glu480, with C-terminal Human IgG1 Fc

QTSVSPSKVILPRGGSVLVTCSTSCDQPKLLGIETPLPKKELLLPGNNRKVYELSNVQEDSQPMCYSNCPDGQSTAKTFLTVYWTPERVELAPLPSWQPVGKNLTLRCQVEGGAPRANLTVVLLRGEKELKREPAVGEPAEVTTTVLVRRDHHGANFSCRTELDLRPQGLELFENTSAPYQLQTFVLPATPPQLVSPRVLEVDTQGTVVCSLDGLFPVSEAQVHLALGDQRLNPTVTYGNDSFSAKASVSVTAEDEGTQRLTCAVILGNQSQETLQTVTIYSFPAPNVILTKPEVSEGTEVTVKCEAHPRAKVTLNGVPAQPLGPRAQLLLKATPEDNGRSFSCSATLEVAGQLIHKNQTRELRVLYGPRLDERDCPGNWTWPENSQQTPMCQAWGNPLPELKCLKDGTFPLPIGESVTVTRDLEGTYLCRARSTQGEVTRKVTVNVLSPRYEIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK

Expression System HEK293
Molecular Weight

49-72kDa (Reducing)

Purity

>95% by SDS-PAGE

Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.

Background

ICAM-1 is a cell-surface glycoprotein and a member of the immunoglobulin (Ig) protein superfamily. ICAM-1 mediates the interaction between keratinocytes and leukocytes. ICAM-1 facilitates a variety of both afferent and efferent immune responses that require intercellular contact and collaboration, including T helper responses, T-dependent B cell responses, antigen-induced T cell proliferation, cell-mediated cytotoxicity, and the binding of leukocytes to vascular endothelium prior to extravasation into inflamed tissue. Pro-inflammatory cytokines interferon-γ and TNF-α stimulate the expression of keratinocyte ICAM-1 and this up-regulation is blocked both in vivo and in vitro if keratinocytes are irradiated with UVB prior to cytokine treatment. In contrast, ICAM-2 is expressed primarily on endothelium and leukocytes (except neutrophils), and its expression generally is not responsive to cytokines. ICAM-3 predominates on thymocytes and resting lymphocytes, which are low in ICAM-1. When neutrophils are activated, they shed the majority of their ICAM-3 into the medium by proteolytic cleavage. In some reports, the expression of ICAM-1 has been positively correlated with a more aggressive tumor phenotype and metastatic potential. For instance, the invasiveness of breast cancer cells has been positively correlated with the expression of ICAM-1. Also, it has been suggested that an ICAM-1–ICAM-1 homophilic interaction between breast cancer cells and mesenchymal stem cells in bone marrow mediates the metastatic expansion of cancer cells, displacing hematopoietic stem cells from their niche.

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SKU: 46250705950

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Lake Worth, US
★★★★★ 5
Good socks
Number of Items: 6, Color: White (6-pairs), Size: X-Large
I have size 13 feet and these are great maybe they’ll stretch and be a bit big but I m fine with that
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Reviewed in the United States on April 30, 2026
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Wendy H.
Birmingham, US
★★★★★ 5
Well made socks
Number of Items: 6, Color: Black (6-pairs), Size: X-Large
Made well. Bought for my Son. He only likes Under Armour brand of socks. Only socks he buys.
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Reviewed in the United States on April 21, 2026
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LC
Carnegie, US
★★★★★ 5
LOVE THEM!!
Size: Small, Color: (001) Black / Black / Castlerock
LOVE! These socks are so comfortable! I wear a 5 in women's and a 3 in big kid shoes. The small fit me perfectly. I see where some say they run small but I can't say that was an issue for me. They are "snug" but thats what you want with a no show sock. I feel they have support vs the ones i used to buy at Walmart. They are very soft! I am actually buying more today and throwing my other ones in the trash!
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Reviewed in the United States on February 18, 2026
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Lucy Mejia
Chelsea, US
★★★★★ 5
So will not write down your foot
Size: Medium, Color: (001) Black / Black / Castlerock
I love these socks. They have a little bit of gel on the top of the heel for support in your tennis shoes and so your socks don’t write down. Very good quality.
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Reviewed in the United States on May 6, 2026
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Twins9
Carnegie, US
★★★★★ 5
Comfy and Stay Put
Size: Medium, Color: (002) Black / Black / Halo Gray
These socks are honestly great. They’re super thin and light, so once you have them on, you kind of forget they’re even there. No bulky feeling in your shoes at all. The best part is they actually stay on. I hate no-show socks that slide down after five minutes, and these don’t do that. The little grip on the heel really works, so you’re not constantly adjusting them all day. They’re breathable too, which is nice if your feet run warm. They dry fast and don’t get that gross sweaty feeling. And there’s no annoying seam on the toe, so nothing rubs or feels uncomfortable. Basically, they’re just comfy, stay put, and don’t cause problems — which is all I want from socks.
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Reviewed in the United States on January 16, 2026

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