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Description
Human ANGPTL3, His tagProduct Specification Species Human Synonyms Angiopoietin 5 (ANG 5), ANGPT5 Accession Q9Y5C1 Expression System HEK293 Molecular Weight Theoretical: 25. 4 kDa Actual: 28 35 kDa Purity 95% by SDS PAGE Endotoxin <1EU mg Tag with C 10*His Physical Appearance Lyophilized Powder Storage Buffer Lyophilized from a 0. 2 m filtered solution of 0. 2M PBS, pH7. 4. Stability & Storage 12 months from date of receipt, 20 to 70 C as supplied. 6 months, 20 to 70 C
Product Specification
| Species | Human |
| Synonyms | Angiopoietin-5 (ANG-5), ANGPT5 |
| Accession | Q9Y5C1 |
| Expression System | HEK293 |
| Molecular Weight | Theoretical:25.4 kDa Actual:28-35 kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/mg |
| Tag | with C-10*His |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
ANGPTL3 is a member of the angiopoietin-like family of secreted factors. It is expressed predominantly in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain, and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. Angptl3 also acts as dual inhibitor of lipoprotein lipase (LPL) and endothelial lipase (EL), thereby increasing plasma triglyceride, LDL cholesterol and HDL cholesterol in mice and humans. In human, ANGPTL3 is a determinant factor of HDL level and positively correlates with plasma HDL cholesterol.
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