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Description
Fc γ RIIIa/CD16a(F176 Protein, S197P) His Tag Protein, HumanProduct Specification Species Human Synonyms Low Affinity Immunoglobulin Gamma Fc Region Receptor III A, CD16a Antigen, Fc Gamma RIII Alpha, Fc Gamma RIII, Fc gamma RIIIa, FcRIII, FcRIIIa, FcR 10, IgG Fc Receptor III 2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3 Accession P08637 1 Amino Acid Sequence Gly17 Gln208, with C terminal His Expression System HEK293 Molecular Weight 35 45 kDa(Reducing) Purity 95%, by SDS PAGE under reducing conditions Endotoxin
Product Specification
| Species | Human |
| Synonyms | Low Affinity Immunoglobulin Gamma Fc Region Receptor III-A, CD16a Antigen, Fc-Gamma RIII-Alpha, Fc-Gamma RIII, Fc-gamma RIIIa, FcRIII, FcRIIIa, FcR-10, IgG Fc Receptor III-2, CD16a, FCGR3A, CD16A, FCG3, FCGR3, IGFR3 |
| Accession | P08637-1 |
| Amino Acid Sequence | Gly17-Gln208, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight | 35-45 kDa(Reducing) |
| Purity | ＞95%, by SDS-PAGE under reducing conditions |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at less than 1 mg/mL according to the size in ultrapure water after rapid centrifugation . |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
IgG Fc receptor (Fc γ R) is a member of the Ig superfamily, which plays a role in activating or inhibiting immune response. Human Fc γ Rs can be divided into three types: RI (CD64), RII (CD32) and RIII (CD16). CD16 is a low-affinity Fc receptor, which has been identified as Fc γ RIII (a (CD16a) and Fc γ RIIIb (CD16b), respectively. These receptors bind to the Fc portion of the IgG antibody and are encoded by two different highly homologous genes in a cell type-specific manner. In humans, CD16a is a 50-70 kDa type I transmembrane activated receptor expressed in NK cells, T cells, monocytes and macrophages, involved in phagocytosis, secretion of enzymes and inflammatory mediators, antibody-dependent cytotoxicity and clearance of immune complexes. Abnormal expression or mutation of CD16a is associated with susceptibility to viral infection, systemic lupus erythematosus and neutropenia in alloimmune newborns. In humans, mutations in a single amino acid of CD16a may affect susceptibility to autoimmune diseases or response to therapeutic IgG antibodies.
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