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Description
HSF1 Recombinant Rabbit mAb (S-3139-44)Product Specification Host Rabbit Antigen HSF1 Synonyms Heat shock factor protein 1; HSF 1; Heat shock transcription factor 1Imported (HSTF 1); HSTF1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q00613 Clone Number S 3139 44 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms Positive Sample PC 3, HeLa, K562, NIH 3T3 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated
Product Specification
| Host | Rabbit |
| Antigen | HSF1 |
| Synonyms | Heat shock factor protein 1; HSF 1; Heat shock transcription factor 1Imported (HSTF 1); HSTF1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q00613 |
| Clone Number | S-3139-44 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms |
| Positive Sample | PC-3, HeLa, K562, NIH/3T3 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:1000 | Hu |
| ICC | 1:500 | Hu, Ms |
| IF | 1:500 | Hu |
Background
Heat shock factor 1 (HSF1) is an evolutionarily conserved transcription factor that acts as the master regulator of the inducible heat-shock response by binding to heat-shock elements (HSEs) in the promoters of cytoprotective chaperone genes such as HSP70 and HSP90, thereby driving rapid expression of molecular chaperones that prevent stress-induced protein misfolding and aggregation; beyond this canonical cytoprotective role, HSF1 also modulates diverse cellular processes including development, metabolism, apoptosis and aging, is frequently hijacked by cancers to sustain oncogenic protein homeostasis and promote malignant proliferation, and is therefore emerging as a key therapeutic target in both protein-misfolding disorders and cancer.
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