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Description
FGF-10 Protein, MouseProduct Specification Species Mouse Synonyms FGF 10, Fibroblast Growth Factor 10, FGFA, Keratinocyte growth factor 2, KGF2 Accession O35565 Amino Acid Sequence Ser62 Thr209 Expression System E. coli Molecular Weight 17kDa Purity >95% by SDS PAGE & RP HPLC Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 50mM NaCl, 2mM DTT, pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according
Product Specification
| Species | Mouse |
| Synonyms | FGF-10, Fibroblast Growth Factor-10, FGFA, Keratinocyte growth factor-2, KGF2 |
| Accession | O35565 |
| Amino Acid Sequence | Ser62-Thr209 |
| Expression System | E.coli |
| Molecular Weight | 17kDa |
| Purity | >95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 50mM NaCl, 2mM DTT, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Hubert F. et al. (2022) FGF10 promotes cardiac repair through a dual cellular mechanism increasing cardiomyocyte renewal and inhibiting fibrosis. Cardiovasc Res. 118(12): 2625-2637. 2、Sun W. et al. (2019) Cytokine fibroblast growth factor 10 (FGF10) polymorphisms are associated with risk of myopia in young children. J Cell Biochem. 120(9): 15241-15247. |
Background
Fibroblast growth factor 10 (FGF-10), a secreted heparin-binding protein, is a member of the fibroblast growth factor (FGF) family and is also known as Keratinocyte Growth Factor-2 (KGF-2). FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF-10 exhibits mitogenic activity for keratinizing epidermal cells, but essentially no activity for fibroblasts, which is similar to the biological activity of FGF7. Studies revealed that genetic variants of FGF10 were associated with extreme myopia in adults.
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