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Description
Galectin-3 Protein, HumanProduct Specification Species Human Synonyms 35 kDa Lectin, Carbohydrate binding protein 35 (CBP 35), Galactose specific Lectin 3, Galactoside binding protein (GALBP) Amino Acid Sequence Ala2 Ile250 Expression System E. coli Molecular Weight 30kDa (Reducing) Purity 95% by SDS PAGE & RP HPLC Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4, 2mM DTT Reconstitution Reconstitute at 0. 1
Product Specification
| Species | Human |
| Synonyms | 35 kDa Lectin, Carbohydrate-binding protein 35 (CBP 35), Galactose-specific Lectin 3, Galactoside-binding protein (GALBP) |
| Amino Acid Sequence | Ala2-Ile250 |
| Expression System | E.coli |
| Molecular Weight | 30kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4, 2mM DTT |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
Galectin-3 (Gal-3) is a member of the galectin family of carbohydrate binding proteins which have affinity for beta-galactoside. Gal-3 is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. Gal-3 can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. Gal-3 is expressed in the nucleus, cytoplasm, mitochondrion, cell surface and extracellular space, and plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation and exhibits antimicrobial activity against bacteria and fungi. Alternate splicing results in multiple transcript variants, Gal-3 plays an important role in the pathogenesis of neuroinflammatory and neurodegenerative disorders, such as multiple sclerosis, Alzheimer's disease, Parkinson's disease, and Huntington's disease. On the other hand, there is also evidence of the protective role of Gal-3 due to its anti-apoptotic effect in target cells.
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