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Description
PPP2R1A Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen PPP2R1A Synonyms Serine threonine protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; PP2Aa; Medium tumor antigen associated 61 kDa protein; PP2A subunit A isoform PR65 alpha; PP2A subunit A isoform R1 alpha Immunogen Synthetic Peptide Location Nucleus, Cell membrane Accession P30153 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample
Product Specification
| Host | Rabbit |
| Antigen | PPP2R1A |
| Synonyms | Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; PP2Aa; Medium tumor antigen-associated 61 kDa protein; PP2A subunit A isoform PR65-alpha; PP2A subunit A isoform R1-alpha |
| Immunogen | Synthetic Peptide |
| Location | Nucleus, Cell membrane |
| Accession | P30153 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, Ramos, HepG2, HEK-293, NIH/3T3, RAW264.7, mouse liver, C6, COS-7 |
| Predicted Reactivity | Bv |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:500 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms, Rt |
Background
PPP2R1A (Protein Phosphatase 2 Regulatory Subunit A Alpha) is a core scaffold subunit of the serine/threonine phosphatase PP2A, essential for assembling the catalytic C and regulatory B subunits into an active holoenzyme that dephosphorylates hundreds of substrates, thereby governing cell-cycle progression, apoptosis, metabolism, epithelial-mesenchymal transition, and antiviral signaling; it localizes to the cytoplasm and nucleus, is frequently mutated at hotspots in ovarian, endometrial and laryngeal cancers, undergoes post-translational succinylation that switches its function from tumor suppressor to oncogene by rewiring gluconeogenesis/lipogenesis, and its expression or mutation status modulates Wnt, TGF-β, PI3K-AKT and Hippo-YAP pathways, making it a key prognostic and therapeutic target in cancer and inflammatory diseases.
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