GDNF Receptor alpha 1/GFRA1 Recombinant Rabbit mAb (S-3289-52)
SKU: 23203722635

GDNF Receptor alpha 1/GFRA1 Recombinant Rabbit mAb (S-3289-52)

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Description

GDNF Receptor alpha 1/GFRA1 Recombinant Rabbit mAb (S-3289-52)Product Specification Host Rabbit Antigen GDNF Receptor alpha 1 GFRA1 Synonyms GDNF family receptor alpha 1; GDNF receptor alpha 1; GDNFR alpha 1; GFR alpha 1; RET ligand 1; TGF beta related neurotrophic factor receptor 1; GDNFRA; RETL1; TRNR1 Immunogen Synthetic Peptide Location Endosome, Cell membrane Accession P56159 Clone Number S 3289 52 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample MCF7

Product Specification


Host Rabbit
Antigen GDNF Receptor alpha 1/GFRA1
Synonyms GDNF family receptor alpha-1; GDNF receptor alpha-1; GDNFR-alpha-1; GFR-alpha-1; RET ligand 1; TGF-beta-related neurotrophic factor receptor 1; GDNFRA; RETL1; TRNR1
Immunogen Synthetic Peptide
Location Endosome, Cell membrane
Accession P56159
Clone Number S-3289-52
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P
Reactivity Hu
Positive Sample MCF7
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
IHC-P 1:1000 Hu

Background

GDNF family receptor alpha-1 (GFRA1) is a 465-amino-acid, glycosylphosphatidylinositol-anchored cell-surface glycoprotein that functions as the high-affinity ligand-binding component for glial-cell-line-derived neurotrophic factor (GDNF) and its close homolog neurturin; upon ligand binding GFRA1 nucleates formation of a tripartite complex that recruits and trans-activates the transmembrane tyrosine kinase RET, thereby triggering downstream survival, proliferation and neurite-outgrowth signals (PI3K/AKT, RAS/MAPK, PLCγ) in dopaminergic, motor, sensory and enteric neurons, and this same GFRA1-mediated signaling is essential during kidney morphogenesis, spermatogenesis and peripheral-nerve repair while also being implicated in cancer chemoresistance and Parkinson’s disease.

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SKU: 23203722635

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4.8 ★★★★★
Based on 489 reviews
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Product Reviews
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Verified Purchase
Austin & Cambria
Houston, US
★★★★★ 5
That ending 😫
Format: Kindle
I fell into a false sense of security and really thought this was gearing towards a happy ending. Then I realized there’s no work they don’t punish Andrew. I really liked Vale’s character. I don’t normally read books with pregnancy but going into this knowing she was pregnant made it more enjoyable for me. I loved Bishops devotion to her and her happiness. I also loved that Holt and Mercy couldn’t fight their attraction to her. I love scent matches so very much. I’m so curious to see how this duet will end up. And I need to pay more attention and notice that a book I’m starting is a duet to begin with lol
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 21, 2025
S
Verified Purchase
Sarah A
Houston, US
★★★★★ 5
oh wow
Format: Kindle
I just knew there was something about Cooper! I’m wondering if he’s about to be included but damn I’m glad he’s at least not a rapist and creepy guy, he just got called on assignment and had to go! This should be interesting! She’s gonna run and then what’s his face is gonna grab her. I’m worried! Wow that was a great book and cliffhanger! Loving this!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 27, 2025
R
Verified Purchase
Ruth Ann Burt
Grantham, US
★★★★★ 5
Great book
Format: Kindle
I absolutely feel in love with all 4 characters!!! The bedroom scenes were 🌋🌡🔥🔥🔥. I couldn't put this book down!!! I'm hooked for the whole series Book 2 here I come!!!!! Its a fun easy book and story to read!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 4, 2024
D
Verified Purchase
Danyelle
Lake Worth, US
★★★★★ 4
Fun with a late blooming omega
Format: Kindle
I like this book. The story is fun, cute, and sexy. There's just a little drama, some excellent, steamy scenes, and a fairly good relationship building storyline. I especially like how all the main characters are a bit older than the usual 20 somethings I tend to see in this kind of book. Having said that, I wish there were more descriptions of the places, as well as the food in the fancy restaurant. I enjoyed the cocktails at the club, so I missed that kind of detail when Gray took Madison on a dinner date. I also wish there had been more interaction between Lucas and Madison, and Lucas and Rian. It felt a bit lopsided, with a focus on Rian, Madison, and Gray. I wish it had been proofread - there are a lot of typos, but nothing too distracting.
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Reviewed in the United States on September 12, 2022
J
Verified Purchase
Jennifer G
Birmingham, US
★★★★★ 3
Madison Deserved Better
Format: Kindle
Madison was a beta...except she wasn't any longer. She was a late presenting Omega. And she was struggling. She was tall and thin, not tiny and curvy. She was opinionated. She was everything an Omega was not. After suffering through her first heat, her friends took her to Ardor, a club where Omegas came to safely find Alphas. She's not expecting much but then she connects with a sexy beta. And when she meets his Alphas, they set her body on fire. Maybe, she's found her no-strings-attached heat pack. Maybe, she's found something more. I could not connect with the characters in this book, so their story never resonated with me. And there was no love story; there was sex. Grey made it clear from the beginning that he had a true love and it was his beta boy, Rian. He went so far as to reassure Rian “Say the word, I’ll never touch her again. Lucas can put the babies in her. I only need you, beta boy”. So, Madison was there for babies, no emotions needed. Nice. No, thank you. I want the Omega to be the center of their world, not an incubator. Lucas and Rian weren't any better. After her heat, they let her leave. Not one of them made her feel valued. No one gave her a reason to stay or even offered a cuddle. And the sex didn't even come across as mind-blowing. Madison deserved better.
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Reviewed in the United States on March 11, 2025

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