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Description
Human Antithrombin-III, His tagProduct Specification Species Human Synonyms ATIII, Serpin C1 Accession P01008 Amino Acid Sequence Protein sequence(P01008, His33 Lys464, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | ATIII, Serpin C1 |
| Accession | P01008 |
| Amino Acid Sequence | Protein sequence(P01008, His33-Lys464, with C-10*His) |
| Expression System | HEK293 |
| Molecular Weight | Theoretical: 50.7kDa Actual: 65kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
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Background
Antithrombin III is a plasma protease inhibitor and a member of the serpin superfamily. This protein inhibits thrombin as well as other activated serine proteases of the coagulation system, and it regulates the blood coagulation cascade. The protein includes two functional domains: the heparin binding-domain at the N-terminus of the mature protein, and the reactive site domain at the C-terminus. The inhibitory activity is enhanced by the presence of heparin. Numerous mutations have been identified for this gene, many of which are known to cause antithrombin-III deficiency which constitutes a strong risk factor for thrombosis. A reduction in the serum level of this protein is associated with severe cases of Coronavirus Disease 19 (COVID-19).
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