sFlt-1 Recombinant Rabbit mAb (SDT-233-26)
SKU: 36534934092

sFlt-1 Recombinant Rabbit mAb (SDT-233-26)

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Description

sFlt-1 Recombinant Rabbit mAb (SDT-233-26)Product Specification Host Rabbit Antigen sFlt 1 Synonyms Soluble Fms Like Tyrosine Kinase 1, sVEGFR 1 Immunogen Recombinant Protein Accession P17948 Clone Number SDT 233 26 Antibody Type Recombinant mAb Application CLIA, Sandwich ELISA Reactivity Hu Cross Reactivity Does not recognize PlGF Purification Protein A Concentration 2 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300

Product Specification


Host Rabbit
Antigen sFlt-1
Synonyms Soluble Fms-Like Tyrosine Kinase-1, sVEGFR-1
Immunogen Recombinant Protein
Accession P17948
Clone Number SDT-233-26
Antibody Type Recombinant mAb
Application CLIA, Sandwich ELISA
Reactivity Hu
Cross Reactivity Does not recognize PlGF
Purification Protein A
Concentration 2 mg/ml
Purity >95% by HPLC
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer PBS pH7.4, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
Sandwich ELISA N/A

Background

Soluble fms-like tyrosine kinase-1 (sFlt-1 or sVEGFR-1) is a tyrosine kinase protein with antiangiogenic properties. A non-membrane associated splice variant of VEGF receptor 1 (Flt-1), sFlt-1 binds the angiogenic factors VEGF (vascular endothelial growth factor) and PlGF (placental growth factor), reducing blood vessel growth through reduction of free VEGF and PlGF concentrations. In humans, sFlt-1 is important in the regulation of blood vessel formation in diverse tissues, including the kidneys, cornea, and uterus. Abnormally high levels of sFlt-1 have been implicated in the pathogenesis of preeclampsia. Preeclampsia (PE) is a hypertensive pregnancy disorder that occurs in approximately 2% to 4% of all pregnancies and is accompanied by substantial morbidity and mortality for both mother and infant and long-term risks for chronic diseases. The exact causes of PE are still unclear, but contributors are systemic endothelial dysfunction, impaired angiogenesis, and decreased vascular compliance. In recent years, research has focused primarily on soluble anti-angiogenic factors, such as soluble fms-like tyrosine kinase-1 (sFlt-1) and pro-angiogenic factors, such as placental growth factor (PlGF). An anti-angiogenic imbalance upon increased sFlt-1 levels has been shown to be a critical factor in the pathogenesis of placentally associated disorders such as PE and is strongly associated with the crucial process of remodelling of the maternal spiral arteries. As an anti-angiogenic factor on the surface of vascular endothelial cells, sFlt-1 blocks the responses of the pro-angiogenic factors vascular endothelial growth factor (VEGF) and PlGF. Those changes in the concentration of angiogenic factors can be measured in maternal blood samples–an elevated sFlt-1/PlGF ratio can occur weeks before clinical symptoms of PE arise. Therefore, measurement of the sFlt-1/PlGF ratio has become an established marker in clinical practice for early prediction of PE.

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SKU: 36534934092

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Patrice Kimmerle
Chelsea, US
★★★★★ 5
Good quality and fit. Lightweight sweater.
Great lightweight sweater. Quality fabric and good fit.
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Reviewed in the United States on December 29, 2025
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MJ
West Palm Beach, US
★★★★★ 4
Boyfriend liked it, however it has a weird fit
I got this for my boyfriend as he is a fan of this brand's clothes. I got him small and I am glad I did. Although it looks fantastic on him because he is him, the sweater is strangely long and has a weird tough material to it. It is not exactly soft to the touch, and it has a weird stretch. It doesn't feel like other COOFANDY brand turtlenecks he owns, so I was surprised at how stiff the material was compared to those. The color is also a bit more orange in person.
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Reviewed in the United States on December 23, 2023
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R. C. J.
Phoenix, US
★★★★★ 5
Ribbing & AComfortable Fit
I stumbled onto this brand as the sizes & sizing were very accurate. The ribbed feature is a blessing as it masks, hides, conceals stains & or body imperfections. I'm a 63 year old grandpa who greets outside in the Midwest at church 50 weeks a year. The warmth, the longer sleeve's and the high & roll up, roll down turtle neck is super cozy. The value is, it looks more expensive than it actually was, I have already ordered another in black. I am 5'8 298# with a 63 inch chest 48 inch waist fits with room to spare.
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Reviewed in the United States on January 23, 2024
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barbara carreno
Grantham, US
★★★★★ 5
Good 👍
Muy bonito igual ala foto
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Reviewed in the United States on May 12, 2026
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Kathryn Chester
Phoenix, US
★★★★★ 5
Very nice turtleneck
I bought this for my husband as a Christmas present. He loves it! He says it fits well, not to heavy and is very comfortable.
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Reviewed in the United States on January 4, 2025

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