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Description
Human MX1, His tagProduct Specification Species Human Synonyms Interferon induced protein p78 (IFI 78K), Interferon regulated resistance GTP binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1 Accession P20591 Amino Acid Sequence Protein sequence (P20591, Ala37 Glu366, with C 10*His)
Product Specification
| Species | Human |
| Synonyms | Interferon-induced protein p78 (IFI-78K), Interferon-regulated resistance GTP-binding protein MxA, Myxoma resistance protein 1, Myxovirus resistance protein 1 |
| Accession | P20591 |
| Amino Acid Sequence | Protein sequence (P20591, Ala37-Glu366, with C-10*His) AENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEGGGGSHHHHHHHHHH |
| Expression System | E.coli |
| Molecular Weight | Predicted MW: 38.4 kDa Observed MW: 43 kDa |
| Purity | ＞90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Tag | with C-10*His |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage | 12 months from date of receipt, -20 to -70 °C as supplied. 6 months, -20 to -70 °C under sterile conditions after reconstitution. 1 week, 2 to 8 °C under sterile conditions after reconstitution. Please avoid repeated freeze-thaw cycles. |
Background
Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene. This cytoplasmic protein is a member of both the dynamin superfamily and the family of large GTPases. MX1 is an antiviral protein that confers resistance to RNA viruses. MX1 has GTPase activity, and GTP-bound MX1 adopts a conformation that enables interaction with viral nucleocapsids. This interaction blocks transport of viral nucleocapsids to the nucleus, which prevents transcription of the viral genome. Structural studies suggest that the antiviral activity of MX1 involves the formation of MX1 oligomeric rings around viral nucleocapsids. In mice, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection.
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