Tau (phospho T181) Mouse mAb (SDT-200-9)
SKU: 45951046873

Tau (phospho T181) Mouse mAb (SDT-200-9)

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Description

Tau (phospho T181) Mouse mAb (SDT-200-9)Product Specification Host Mouse Antigen Tau (phospho T181) Synonyms p Tau181, phospho T181 Immunogen Synthetic Peptide Accession P10636 Clone Number SDT 200 9 Antibody Type Mouse mAb Isotype IgG1,k Application Sandwich ELISA Reactivity Hu, Ms Predicted Reactivity Hu, Ms Cross Reactivity Does not recognize total Tau Purification Protein G Concentration 5 mg ml Purity >95% by HPLC Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS

Product Specification


Host Mouse
Antigen Tau (phospho T181)
Synonyms p-Tau181, phospho T181
Immunogen Synthetic Peptide
Accession P10636
Clone Number SDT-200-9
Antibody Type Mouse mAb
Isotype IgG1,k
Application Sandwich ELISA
Reactivity Hu, Ms
Predicted Reactivity Hu, Ms
Cross Reactivity Does not recognize total Tau
Purification Protein G
Concentration 5 mg/ml
Purity >95% by HPLC
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt, 2 to 8 °C as supplied

Dilution


application dilution species
Sandwich ELISA N/A

Background

Accumulation of intraneuronal neurofibrillary tangles (NFTs) containing paired helical filaments (PHFs) of the microtubule-associated protein tau is one of the defining neuropathological hallmarks of Alzheimer’s disease (AD). The tau protein has an N-terminal projection domain, a proline-rich region, a repeat region, and a C-terminal domain, with multiple potential phosphorylation sites along all regions. Studies using preparations of PHFs and immunohistochemical staining of postmortem brain tissue with specific tau antibodies established that PHF tau is hyperphosphorylated. High levels of p-tau and total tau (t-tau) have consistently been found in cerebrospinal fluid (CSF) of AD patients. However, while CSF t-tau is considered a non-specific biomarker of neuronal injury, p-tau may reflect AD-related tau pathology in the brain. The vast majority of CSF studies have used immunoassays detecting tau phosphorylated at threonine (Thr) 181 (p-tau181). During the last 2 decades, CSF p-tau181 together with total tau (t-tau) and amyloid-β 42 (Aβ42) have been extensively validated as biomarkers of AD and are currently widely used as diagnostic criteria in research studies, in clinical practice in some countries, and for patient selection in clinical trials. CSF p-tau181 (alone or in combination with Aβ42) accurately differentiates AD from controls and predicts cognitive decline in preclinical and prodromal disease stages. CSF p-tau181 levels are higher in AD compared with other tauopathies including frontotemporal dementia (FTD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD) and, hence, CSF p-tau181 has also been proven useful in differential diagnosis of dementia.

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SKU: 45951046873

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Dr. Ana's books are always such a pleasure to read. They are filled with divine knowledge and revelation and this book is no exception...it is like water for a thirsty soul. It gives a divine perspective to the spiritual reality that we have devalued so much in exchange for the comfort of a world we have built for our own comfort. This book offers a lot to process and it has left me wanting more...particularly in the area of connecting and living from our celestial body.
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Jessica L. Jensen
West Palm Beach, US
★★★★★ 5
Looks good works great
Item Package Quantity: 1, Color: Black
This paper towel holder is simple, sturdy, and works exactly as it should. It holds the roll securely and makes it easy to tear off sheets with one hand. The design is clean and attractive, so it looks great on the countertop without taking up too much space. No assemble required and a great value overall.
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VFlorida
Omaha, US
★★★★★ 5
Functional and beautiful!
Item Package Quantity: 1, Color: Silver
This towel holder is a fantastic find! It is always great when a product exceeds your expectations and this towel holder is exactly that. At first, I was not sure if the price was worth it but when I opened the box, I was pleasantly surprised by the quality of the product. It is solid and well made with a heavy base that makes pulling paper towels with one hand a breeze. The mandrel is thick and provides excellent rotational ability. Overall A+. I highly recommend spending a few extra bucks on a functional piece that enhances the overall appearance of a kitchen.
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Laura Maness
Belleville, US
★★★★★ 5
Looks good works great
Item Package Quantity: 1, Color: Silver
This is a nice paper towel holder. I keep it on my counter and it looks great. Its easy to use although I haven't tried it one handed. I like it and I think it was a good price. It was very heavy and works great.
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