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Description
DNAM-1/CD226 His Tag Protein, HumanProduct Specification Species Human Accession Q15762 Amino Acid Sequence Glu19 Asn247, with C terminal 8*His EEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNGGGSHHHHHHHH Expression System HEK293 Molecular Weight 44 57 kDa(Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g
Product Specification
| Species | Human |
| Accession | Q15762 |
| Amino Acid Sequence | Glu19-Asn247, with C-terminal 8*His EEVLWHTSVPFAENMSLECVYPSMGILTQVEWFKIGTQQDSIAIFSPTHGMVIRKPYAERVYFLNSTMASNNMTLFFRNASEDDVGYYSCSLYTYPQGTWQKVIQVVQSDSFEAAVPSNSHIVSEPGKNVTLTCQPQMTWPVQAVRWEKIQPRQIDLLTYCNLVHGRNFTSKFPRQIVSNCSHGRWSVIVIPDVTVSDSGLYRCYLQASAGENETFVMRLTVAEGKTDNGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 44-57 kDa(Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
Background
DNAX accessory molecule 1 (DNAM-1; CD226) is a costimulatory molecule belonging to the immunoglobulin superfamily. DNAM-1 is primarily expressed on NK and CD8 T cells, which has been shown to enhance the cytotoxic effector function of NK cells and T cells against tumor- and virus-infected cells. DNAM-1 is a member of the Ig superfamily, encoded by a gene on human chromosome 18q22.3, is expressed by human NK cells, T cells, a subset of B cells, monocytes and platelets. Interactions between DNAM-1 on NK cells and its ligands on tumour cells augments the NK cell–mediated cytotoxicity and cytokine production. CD155 and its related family member CD112, the known ligands for DNAM-1, broadly expressed on hematopoietic, epithelial, and endothelial cells. Moreover, it was shown that the interaction of DNAM-1 with CD112 and CD155 contributes to the NK-mediated lysis of both imDCs and mDCs. NK cells also express CD96, which shows only ~20% homology to DNAM-1 but was also shown to recongnize CD155 and promote NK cell adhesion and activation. Decreased NK cell activity has been observed in patients with PDAC, and pancreatic cancer patients have less CD226+ NK cells in the blood than do healthy controls. Dysregulation of DNAM-1 is associated with susceptibility to juvenile idiopathic arthritis, type 1 diabetes (T1D), lupus, and rheumatoid arthritis in patients.
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4.1 ★★★★★
Based on 28 reviews
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Product Reviews
★★★★★ 5
Great balls of fun!
Size: Large, Color: Ball-Red
One of the best toys that was ever made! My wife likes to put little treats in there and I'll bat the ball around. The room gives their hours of entertainment. She puts little things like hands of corn i
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Reviewed in the United States on May 6, 2026
★★★★★ 3
Choking hazard from Internal Pieces if Ball
Size: Large, Color: Ball-Blue
The Ball is Very Tough. However, the inside Parts Broke and Fall out and can be Choking Hazard.
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Reviewed in the United States on March 22, 2026
★★★★★ 5
Great for chewers!
Size: Large, Color: Ball-Blue
We have a super high energy one year old pup who destroys practically every toy she gets. This one is excellent! It makes a fun but not annoying sound and she hasn’t been able to destroy it yet. The test hole is a fun addition to keep her busy.
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Reviewed in the United States on November 16, 2025
★★★★★ 5
Very sturdy toy for aggressive chewers
Size: Large, Color: Bone-Blue
My 80-pound American Bully loves this toy. It is very sturdy. Good price. Highly recommend.
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Reviewed in the United States on April 24, 2026
★★★★★ 1
My Dog Loved It—Until It Stopped Working
Size: Large, Color: Ball-Red
I purchased this treat-dispensing dog toy for my German Shepherd, and for the first couple of days it worked exactly as advertised. When rolled or tossed, it made an engaging sound that immediately caught my dog’s attention and encouraged him to interact with the toy to get the treats out. He absolutely loved it.
Unfortunately, after only a few days, the sound feature stopped working. Then it mysteriously started working again for a short period, so I thought the issue had resolved itself. However, it has now stopped completely. No matter how much I shake, roll, or toss the toy, it no longer makes any sound.
I went out of town and didn’t realize the return window had passed while I was gone. By the time I returned, the return deadline had already expired, which was disappointing because I would have returned it when the problem first appeared.
Based on my experience, I cannot recommend purchasing this toy. While many of the reviews seem positive, perhaps I received a defective unit. It’s disappointing that it stopped functioning properly after barely a month of use.
That said, my dog genuinely enjoyed it when it was working, and I would appreciate it if the manufacturer would stand behind their product and offer a replacement as a courtesy. I would be happy to return the defective toy. If a replacement performed as intended, I would gladly reconsider my opinion.
For now, however, I am very disappointed with the functionality and reliability of this product.
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Reviewed in the United States on June 5, 2026