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Description
IP-10/CXCL10 Protein, HumanProduct Specification Species Human Synonyms C7, crg 2, gIP 10, IFI10, INP10, IP 10, mob 1, SCYB10, CXCL10 Accession P02778 Amino Acid Sequence Val22 Pro98 Expression System E. coli Molecular Weight 10 11kDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM Tris, 500mM NaCl, 1mM TCEP, pH8. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in
Product Specification
| Species | Human |
| Synonyms | C7, crg-2, gIP-10, IFI10, INP10, IP-10, mob-1, SCYB10, CXCL10 |
| Accession | P02778 |
| Amino Acid Sequence | Val22-Pro98 |
| Expression System | E.coli |
| Molecular Weight | 10-11kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM Tris, 500mM NaCl, 1mM TCEP, pH8.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Swaminathan G J. et al. (2003) Crystal structures of oligomeric forms of the IP-10/CXCL10 chemokine. Structure. 11(5): 521-532. 2、Booth V. et al. (2002) The CXCR3 binding chemokine IP-10/CXCL10: structure and receptor interactions. Biochemistry. 41(33): 10418-10425. |
Background
IP-10 (Interferon gamma-induced protein 10 or CXCL10) is a proinflammatory cytokine that is secreted by various cell types in response to stimuli such as IFN-γ and LPS. It binds to CXCR3 receptor and regulates chemotaxis, apoptosis, growth, and angiostasis of immune cells. IP-10 is involved in the pathogenesis of many inflammatory disorders, such as autoimmune diseases, HIV infection, and tumour growth. CXCL10 is the chemokine released in highest quantities by islets immediately following islet perfusion in the transplant procedure, as identified by serum samples from 34 patients undergoing islet transplantion. Inflammatory mediators such as physical and chemical stress by isolation and infusion procedures stimulate the release of CXCL10 through an NFAT-MAPK signaling pathway. In particular, interferon-γ release at high concentrations during islet infusion contributes to the stimulation of CXCL10 and the loss of up to 50% of the islet graft immediately following transplant.
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