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Description
CAIX Recombinant Rabbit mAb (SDT-356-21)Product Specification Host Rabbit Antigen CAIX Synonyms CA 9, Carbonic anhydrase 9, Carbonate dehydratase IX, Membrane antigen MN homolog Immunogen Recombinant Protein Location Cytoplasm, Cell membrane Accession Q8VHB5 Clone Number SDT 356 21 Antibody Type Recombinant mAb Application WB, IHC P Reactivity Ms, Rt Purification Protein A Concentration 0. 5 mg ml Tag N A Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03%
Product Specification
| Host | Rabbit |
| Antigen | CAIX |
| Synonyms | CA 9, Carbonic anhydrase 9, Carbonate dehydratase IX, Membrane antigen MN homolog |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm, Cell membrane |
| Accession | Q8VHB5 |
| Clone Number | SDT-356-21 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P |
| Reactivity | Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Tag | N/A |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:8000 |
Background
Carbonic anhydrase IX has been under intensive investigation as a therapeutic target in cancer. Studies demonstrate that this enzyme has a key role in pH regulation in cancer cells, allowing these cells to adapt to the adverse conditions of the tumour microenviroment. Novel CAIX inhibitors have shown efficacy in both in vitro and in vivo pre-clinical cancer models, adversely affecting cell viability, tumour formation, migration, invasion, and metastatic growth when used alone. In co-treatments, CAIX inhibitors may enhance the effects of anti-angiogenic drugs or chemotherapy agents [PMID: 29439394].
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