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Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
For Your Every Summer RSVP, with Code: SUMMER15
Description
MCM2 Recombinant Rabbit mAb (SDT-018-68-2)Product Specification Host Rabbit Antigen MCM2 Synonyms BM28, CCNL1, CDCL1, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28 Immunogen Synthetic Peptide Location Nucleus Accession P49736 Clone Number SDT 018 68 2 Antibody Type Rabbit mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms Purification Protein A Research Area Epigenetics Concentration 0. 5mg ml Molecular Weight 125kDa Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | MCM2 |
| Synonyms | BM28, CCNL1, CDCL1, Minichromosome maintenance protein 2 homolog, Nuclear protein BM28 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P49736 |
| Clone Number | SDT-018-68-2 |
| Antibody Type | Rabbit mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms |
| Purification | Protein A |
| Research Area | Epigenetics |
| Concentration | 0.5mg/ml |
| Molecular Weight | 125kDa |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ICFCM | 1:500 | |
| WB | 1:8000 | |
| IHC-P | 1:1000 | |
| ICC | 1:500 |
Background
MCM2 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. MCM2 forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. MCM2 is phosphorylated, and thus regulated by protein kinases CDC2 and CDC7.
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