SKU: 93749709592

CD40/TNFRSF5 Fc Chimera Protein, Cynomolgus

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Description

CD40/TNFRSF5 Fc Chimera Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50 Accession G7PG38 Amino Acid Sequence Glu21 Arg193, with hIgG1 Fc Expression System HEK293 Molecular Weight 52 58kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Cynomolgus
Synonyms CD40, Bp50, CDW40, MGC9013, TNFRSF5, p50
Accession G7PG38
Amino Acid Sequence

Glu21-Arg193, with hIgG1 Fc

Expression System HEK293
Molecular Weight

52-58kDa

Purity >95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag Human Fc Tag
Physical Appearance Lyophilized Powder
Storage Buffer

PBS, pH7.4

Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

1、van Kooten C. et al. (2000) CD40-CD40 ligand. J Leukoc Biol. 67(1): 2-17.

2、Bhushan A. et al. (2002) CD40: CD40L interactions in X-linked and non-X-linked hyper-IgM syndromes. Immunol Res. 24(3): 311-324.

3、Chatzigeorgiou A. et al. (2009) CD40/CD40L signaling and its implication in health and disease. Biofactors. 35(6): 474-483.

4、Li R. et al. (2009) Expression of CD40 and CD40L in Gastric Cancer Tissue and Its Clinical Significance. Int J Mol Sci. 10(9): 3900-3917.

Lievens D, et al. (2009) The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost. 102(2): 206-14.

Background

CD40 is also known as TNFRSF5, Bp50, CDW40, MGC9013, TNFRSF5 and p50, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins, and plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 is a costimulatory protein found on antigen presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 contains 4 cysteine-rich repeats in the extracellular domain, and is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Interaction of CD40 with its ligand, CD40L, leads to aggregation of CD40 molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Early studies on the CD40-CD40L system revealed its role in humoral immunity. Both CD40 and CD40 L have a membrane form and a soluble form generated by proteolytic cleavage or alternative splicing. CD40 and CD40L are widely expressed in various types of cells, among which B cells and myeloid cells constitutively express high levels of CD40, and T cells and platelets express high levels of CD40L upon activation. CD40L self-assembles into functional trimers which induces CD40 trimerization and downstream signaling. CD40/CD40L immune checkpoint leads to activation of both innate and adaptive immune cells via two-way signaling. CD40/CD40L interaction also participates in regulating thrombosis, tissue inflammation, hematopoiesis and tumor cell fate. The mechanisms of benefits include immune cell activation and tumor cell lysis/apoptosis in malignancies, or immune cell inactivation in autoimmune diseases and allograft rejection.

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SKU: 93749709592

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4.3 ★★★★★
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me
Massapequa, US
★★★★★ 5
Best lip balm I’ve found yet
Every lip balm or chapstick I have ever used has always bothered my lips and made them peel. I’ve tried cheap chapsticks to organic chapsticks to vegan and nothing has ever worked. I figured I’d give this a try since I didn’t have much to lose and I am SO glad I did. This is the first lip balm that hasn’t made my lips peel. I LOVE THIS. And the cinnamon vanilla smells divine. This is definitely going to be my go to from now on.
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Reviewed in the United States on December 19, 2024
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Blythe Hernandez
Lowell, US
★★★★★ 5
LIP GOO GOOD ENOUGH FOR EDS PATIENTS!!! I have old school type3, the super bad…
First of all… I used to have a desserts catering side hustle and my oatmeal scotchie recipe starts smelling EXACTLY like this combo!!! I am 51 and have tried LITERALLY THOUSANDS of chapstick type lip goos, I have a genetic disorder that prevents me from being able to absorb anything… most to all chapsticks DO NOT WORK but my lips are currently soft… it actually feels amazing to have something on my lips that seems to work!!! Instead on sitting on my lips or skin all weird and greasy til I freak out rub everything off!!! It’s working… NOT SOMETHING I WAS ACTUALLY WILLING TO ADMIT TO… My VEGAN MOTHER talked me into trying this, she’s more absorbent and can use other products, I cannot, however!!! I seriously LOVE THIS GOO!!!
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Reviewed in the United States on July 21, 2025
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catherica
Houston, US
★★★★★ 5
you won’t regret it
absolute life saver on a winter trip to austria, and has become my go-to every day since! even before my trip i was struggling with chapped lips and this healed them and protected them through winter sports better than anything i’ve ever used, and i’m a lip balm snob. smells amazing, feels amazing. 10/10!
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Reviewed in the United States on February 12, 2025
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TexasGigi
Draper, US
★★★★★ 5
Wow! So moisturizing!
OMGosh, this feels so good on your lips! I just got this today so I’ll have to update if the moisture doesn’t last. But so far it feels nice. I did have a slight issue with it melting onto itself in the one day it took to get to me. See photos. The tube itself was slightly concave because of the melting. But is still intact. So far though I love this stuff!
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Reviewed in the United States on May 8, 2026
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KS
West Palm Beach, US
★★★★★ 5
Pretty good stuff
Not a miracle cream, but I've certainly paid more for worse lip balm. The tallow is helping keep my lips hydrated, and it feels great when applied. Just got Invisalign, and I struggle with hydration normally, but this is helping keep the lips soft and smooth, and is miles ahead of the cheap drugstore brands that dry more than they help.
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Reviewed in the United States on April 13, 2026

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