Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 7 - Jul 12
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
E-Selectin/CD62E His Tag Protein, MouseProduct Specification Species Mouse Synonyms SELE, RP1 117P20. 2,ELAM1, ESEL, LECAM2 Accession Q00690 Amino Acid Sequence Trp22Pro557, with C terminal His Expression System HEK293 Molecular Weight 72 94KDa (Reducing) Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH 7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water
Product Specification
| Species | Mouse |
| Synonyms | SELE, RP1-117P20.2,ELAM1, ESEL, LECAM2 |
| Accession | Q00690 |
| Amino Acid Sequence | Trp22Pro557, with C-terminal His |
| Expression System | HEK293 |
| Molecular Weight |
72-94KDa (Reducing)
|
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH 7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1.Matsumoto K, et al. (2010) Soluble adhesion molecule E-selectin predicts cardiovascular events in Japanese patients with type 2 diabetes mellitus. Metabolism. 59(3): 320-4. 2.Stancanelli B, et al. (2010) Soluble e-selectin is an inverse and independent predictor of left ventricular wall thickness in end-stage renal disease patients. Nephron Clin Pract. 114(1): c74-80. |
Background
E-selectin, also known as endothelial leukocyte adhesion molecule-1 (ELAM-1) and CD62E, is an inducible adhesion molecule that is expressed on the surfaces of stimulated vascular endothelial cells and is sometimes implicated in cancer cell metastasis. It has a complex mosaic structure that includes a large extracellular region with a lectin domain, an EGF-like domain, and a short consensus repeat (SCR) domain. This is followed by a transmembrane region and a relatively short (32 amino acid) cytoplasmic tail. As part of the LEC-CAM or selectin family, E-selectin recognizes and binds to sialylated carbohydrates, including those from the Lewis X and Lewis A families, which are found on monocytes, granulocytes, and T-lymphocytes. It facilitates the rolling and stable arrest of leukocytes on activated vascular endothelium. Additionally, E-selectin is suggested to transduce activating stimuli via the MAPK signaling cascade during leukocyte adhesion.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy